Antimicrobial peptides : discovery, design and novel therapeutic strategies / edited by Guangshun Wang. - 2nd edition. - 1 online resource (xvii, 268 pages) : illustrations, charts

Includes bibliographical references and index.

Discovery, classification and functional diversity of antimicrobial peptides / Guangshun Wang -- Structural and functional diversity of cathelicidins / Alessandro Tossi, Barbara Skerlavaj, Francesca D'Este and Renato Gennaro -- Disulfide-linked defensins and their therapeutic potential / Monique von Hoek -- Lantibiotics : bioengineering and applications / Brian Healy and Paul Cotter -- Discovery of novel antimicrobial peptides using combinatorial chemistry and high-throughput screening / Charles G. Starr and William C. Wimley -- Prediction and design of antimicrobial peptides: methods and applications to genomes and proteomes / Guangshun Wang -- Antimicrobial peptides, multiple mechanisms against a variety of targets / Li-av Segev-Zarko, Maria Luisa Mangoni and Yechiel Shai -- Microbial membranes and the action of antimicrobial peptides / Jos�e Carlos Bozelli Junior, Shirley Schreier and Richard Epand -- Non-membrane-targeting amps, novel therapeutic opportunities? / Marco Scocchi, Mario Mardirossian, Giulia Runti and Monica Benincasa -- Structural insight into the mechanism of action of antimicrobial peptides and structure-based design / Guangshun Wang -- Synergy of antimicrobial peptides / Moswabar H. Chowdhury, Gill Diamond and Lisa Kathleen Ryan -- Surface immobilization of antimicrobial peptides to prevent biofilm formation / Biswajit Mishra, Scott Reiling and Guangshun Wang -- Sustained delivery of cathelicidin antimicrobial peptide-inducing compounds to minimize infection and enhance wound healing / Jingwei Xie, Gitali Ganguli-Indra,, Arup K. Indra and Adrian Gombart -- Immunomodulatory activities of cationic host defense peptides and novel therapeutic strategies / Kelli C. Wuerth and Robert Hancock.

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This book contains 14 chapters focusing on discovery, classification and functional diversity of antimicrobial peptides; structural and functional diversity of cathelicidins; disulfide-linked defensins; prediction and design of antimicrobial peptides - methods and applications to genomes and proteomes; antimicrobial peptides; microbial membranes and the action of antimicrobial peptides; structural insight into the mechanisms of action of antimicrobial peptides and structure-based design; synergy of antimicrobial peptides; surface immobilization of antimicrobial peptides to prevent biofilm formation; sustained delivery of cathelicidin antimicrobial peptide-inducing compounds to minimize infection and enhance wound healing.



9781786390400 9781786390417


Peptide antibiotics.
Antimicrobial Cationic Peptides
Anti-Infective Agents
Immunity, Innate
Drug Design
Antimicrobial properties.
Biofilms.
Cathelicidins.
Defensins.
Genomes.
Healing.
Human diseases.
Infections.
Methodology.
Peptides.
Proteomes.
Synergism.
Wounds.

RS431.P37 / A575 2017eb

615/.1